{"Abbreviation":["Tremortin"],"Adverse Effects":"Neurotoxin - Other CNS neurotoxin","Aliases":["penitrem A","Tremortin A","Dtxsid00320093","NSC-354845","Dtxcid101031287","21-chloro-15,16,33,33-tetramethyl-24-methylidene-10-(prop-1-en-2-yl)-7,11,32-trioxa-18-azadecacyclo(25.4.2.02,16.05,15.06,8.06,12.017,31.019,30.022,29.025,28)tritriaconta-17(31),19,21,29-tetraene-5,9,28-triol","NSC 354845","Unii-244au85pr7","C37H44ClNO6","CBiol_001846","BSPBio_001431","KBioGR_000151","KBioSS_000151","Schembl353317","Chembl2374089","GTPL14027","KBio2_000151","KBio2_002719","KBio2_005287","KBio3_000301","KBio3_000302","MSK7234","Chebi:176948","Bio1_000132","Bio1_000621","Bio1_001110","Bio2_000151","Bio2_000631","Dtxsid001372721","HMS1361H13","HMS3402H13","HY-N6776","HB1057","Mfcd00083465","Mfcd12547934","Akos024458256","Idi1_033901","Qtl1_000065","Ncgc00163403-01","Ncgc00163403-02","Ncgc00163403-03","Penitrem A, \u003e=95%","BP162742","CS-0029226","NS00075363","C20070","Brd-k03842655-001-02-1","(1S,2R,4R,6R,8S,9S,10R,15R,27S)-21-chloro-4,15,33,33-tetramethyl-24-methylidene-10-prop-1-en-2-yl-7,11,32-trioxa-18-azadecacyclo[25.4.2.02,16.05,15.06,8.06,12.017,31.019,30.022,29.025,28]tritriaconta-17(31),19,21,29-tetraene-5,9,28-triol","(1S,2R,5S,6S,8R,9S,10R,12S,15R,16S,25R,27S,28R)-21-chloro-10-isopropenyl-15,16,33,33-tetramethyl-24-methylene-7,11,32-trioxa-18-azadecacyclo[25.4.2.02,16.05,15.06,8.06,12.017,31.019,30.022,29.025,28]tritriaconta-17(31),19,21,29-tetraene-5,9,28-triol","(2R,3S,3aR,4aS,4bS,6aR,6bS,8aS,9aR,11cR,15aS,15bR,17aS)-12-Chloro-8,8,15a,15b-tetramethyl-10-methylidene-2-(prop-1-en-2-yl)-3,3a,6,6a,6b,8,8a,9,9a,10,11,15a,15b,16,17,17a-hexadecahydro-2H,4bH-14,15-epiminobenzo[fg]cyclobuta[kl]oxireno[4',4a'][1]benzopyrano[6',5':4,5]indeno[1,2-d][3]benzoxocine-3,4b,11c(5H)-triol"],"CAS":"12627-35-9","Chemical Classes":"Biological Agents -\u003e Mycotoxins","ChemicalClasses":["aniline"],"Chirality":"absolute","Classes":["Neurotoxin"],"Erowid Experience Reports":[],"Esters":[],"European Community (EC) Number":"634-132-0","Formating":[],"Health Effects":"Tremorgenic mycotoxins affect central nervous system activity. They cause a neurological disease of horses and cattle known as \"staggers syndrome\". Penitrem A is also genotoxic and causes DNA damage. (A2974, A3026)","HeavyAtomCount":45,"IUPACName":"(1S,2R,5S,6S,8R,9S,10R,12S,15R,16S,25R,27S,28R)-21-chloro-15,16,33,33-tetramethyl-24-methylidene-10-prop-1-en-2-yl-7,11,32-trioxa-18-azadecacyclo[25.4.2.02,16.05,15.06,8.06,12.017,31.019,30.022,29.025,28]tritriaconta-17(31),19,21,29-tetraene-5,9,28-triol","InChI":"InChI=1S/C37H44ClNO6/c1-15(2)28-27(40)31-37(45-31)23(43-28)9-10-33(6)34(7)18(8-11-35(33,37)41)29-25-24-21(39-30(25)34)14-20(38)17-12-16(3)19-13-22(32(4,5)44-29)36(19,42)26(17)24/h14,18-19,22-23,27-29,31,39-42H,1,3,8-13H2,2,4-7H3/t18-,19+,22+,23-,27-,28+,29-,31+,33+,34+,35-,36+,37-/m0/s1","InChIKey":"JDUWHZOLEDOQSR-JKPSMKLGSA-N","MeSH Headers":[{"Id":"M0308352","Link":"https://id.nlm.nih.gov/mesh/M0308352.html","Name":"tremortin A","Ref":34},{"Id":"DescTree","Link":"https://www.nlm.nih.gov/mesh/meshhome.html","Name":"MeSH Tree","Ref":35}],"Metabolism/Metabolites":"Penitrem A is extensively metabolized in the liver to at least five metabolites that are less toxic and more hydrophilic than the parent compound. These metabolites are an oxidated metabolite, an oxidated, dehydrated metabolite, a water adduct, a dioxidated metabolite, and a product of water addition and oxidation. (A2992)","MolecularFormula":"C\u003csub\u003e37\u003c/sub\u003eH\u003csub\u003e44\u003c/sub\u003eClNO\u003csub\u003e6\u003c/sub\u003e","MolecularWeight":"634.2 g/mol","Opticalactivity":"UNSPECIFIED","Physical Description":"Solid; [Aldrich MSDS]","PubChemId":6610243,"Records":{"UNII":{"Impurities":[]}},"RefChem":"171223","RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Penitrem_A","Name":"Penitrem A","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q63409025","Name":"Penitrem A","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/6610243","Name":"Penitrem A","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=12627-35-9","Name":"Penitrem A","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C20070","Name":"Penitrem A","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/244AU85PR7","Name":"Penitrem A","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID00320093","Name":"Penitrem A","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 6610243, penitrem A. Accessed May 6, 2026. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/6610243\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/6610243\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Penitrem A. UNII: 244AU85PR7. Global Substance Registration System. Accessed May 6, 2026. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/244AU85PR7\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/244AU85PR7\u003c/a\u003e"],"SMILES":"CC(=C)[C@@H]1[C@@H]([C@@H]2[C@@]3(O2)[C@@H](O1)CC[C@]4([C@]3(CC[C@@H]5[C@@]4(C6=C7[C@H]5OC([C@H]8C[C@H]9[C@@]8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O","SaltData":[],"Salts":[],"StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 169.798 135.897\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h170v136H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m148.709 1.001 4.7 14.497\" 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1.22-.529.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M168.597 49.482h-.619v-2.286h-2.512v2.286h-.614v-4.9h.614v2.072h2.512v-2.072h.619z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m131.928 24.413 5.639 1.202M75.488 112.211l-3.995 3.99\" class=\"hi\"/\u003e\u003cpath stroke=\"#1ff01f\" d=\"m17.989 62.638 5.151 4.321\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m56.843 62.171-4.63 3.36M56.843 62.171l-4.63 3.36M62.99 62.176l4.625 3.365M62.99 62.176l4.625 3.365\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Subjective Effects":null,"Title":"Penitrem A","Toxicity Data":"LD50: 10 mg/kg (Oral, Mouse) (A2992)\nLD50: 1.1 mg/kg (Intraperitoneal, Mouse) (A2992)","Treatment":"To control severe tremors caused by tremorgenic mycotoxins, methocarbamol should be administered. Generalized seizures may be treated with diazepam followed by methocarbamol or a barbiturate such as pentobarbital sodium. Gastric lavage should be performed and activated charcoal administered to limit further absorption of toxins. (A744)","UNII":"244AU85PR7","Wikidata":"Q63409025","Wikipedia":"Penitrem_A","XLogP":3.8}